Brain Metastasis is Associated with Tumor Size, Nodal Status, and c-erbB-2 Expression in Invasive Breast Carcinoma

Abstract Introduction According to the World Health Organization (WHO) classification, invasive breast carcinoma (IBC) of no special type (IBC-NST) is second most common primary site central nervous system metastases, affecting 15% 30% patients. Brain metastasis originating from IBC associated with patient age, tumor size, and axillary lymph node status. Loss expression hormone receptors c-erbB-2 amplification are frequent findings in patients who develop brain metastasis. Radiological studies carried out only presenting neurological signs or symptoms during clinical follow-up. Objective To evaluate associations pathological cancer. Materials Methods The sample comprised 73 cancer underwent mastectomy resection. following variables were evaluated: histological grade, nodal state, estrogen progesterone c-erbB-2, presence Results histopathological size (p = 0.03), 0.045), 0.012). Conclusion assessment specific can help identify risk factors and/or parameters development